Many fonts on Typekit support Spanish. You can browse fonts that support Spanish by selecting "Spanish" from the list of supported languages in the sidebar under browse fonts.
All fonts that support Spanish include (at minimum) the following letter characters:
| A | B | C | D | E | F | G | H |
| I | J | K | L | M | N | O | P |
| Q | R | S | T | U | V | W | X |
| Y | Z | a | b | c | d | e | f |
| g | h | i | j | k | l | m | n |
| o | p | q | r | s | t | u | v |
| w | x | y | z | ¡ | ¿ | Á | É |
| Í | Ñ | Ó | Ú | Ü | á | é | í |
| ñ | ó | ú | ü |